Mitodepressive effect of khat extract in the meristematic region of Allium cepa root tips.

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Abstract
The khat extract showed a mitodepressive effect on the rate of cell division in A. cepa root tips. This effect increased as the time of exposure increased, until it reached a maximum of complete inhibition of cell division after exposure. In the short treatment time of khat extract, the root tips showed a slight increase in the mitotic index after a period of recovery in water. The increase was greater with a more extended time of recovery. But after long treatment time (24 h), 4 h recovery was not enough to bring back the cell division. The longer the exposure, the longer the recovery time needed. The harmful effect of khat on the rate of cell division of A. cepa root tips caused an imbalance in the frequencies of mitotic phases [metaphase arrest].

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