Products of Cytochrome P450BioI (CYP107H1)-Catalyzed Oxidation of Fatty Acids
- 15 August 2003
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (18) , 3341-3344
- https://doi.org/10.1021/ol035254e
Abstract
[reaction: see text] Oxidation of tetradecanoic and hexadecanoic acids by cytochrome P450(BioI) (CYP107H1) produces mainly the 11-, 12-, and 13-hydroxy C(14) fatty acids and the 11- to 15-hydroxy C(16) fatty acids, respectively. In contrast to previous reports, terminal hydroxylation is not observed. The enantiospecificity of fatty acid hydroxylation by P450(BioI) was also determined, and the enzyme was shown to be moderately selective for production of the (R)-alcohols.Keywords
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