Factors affecting the toxicity of diazinon to Musca domestica L

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Abstract
SUMMARY: Processes affecting the toxicity of diazinon to a susceptible and a resistant strain of houseflies were examined.More evidence was obtained to show that slower penetration of diazinon through the integument of resistant flies is a cause of resistance.Small amounts of two decomposition products were found in both strains. The decomposition mechanisms, in these strains were differently distributed and, although detoxication of diazinon in the two strains is quantitatively similar and small, it may contribute to resistance.Traces of diazoxon were detected when diazinon was incubated with tissue extracts of either strain.Tissue extracts of resistant, but not of susceptible, flies decomposed significant amounts of diazinon in 1 hr. and the ability to decompose diazoxon seems to be an important cause of resistance.Tissues of both strains sorbed diazinon from aqueous solution similarly; the quantities sorbed were large and suggest that sorption may increase the amount of poison needed inside the insects to kill, by between five and forty times.