THE PRODUCTION OF POLYCYTHEMIA BY COBALT IN RATS MADE ANEMIC BY A DIET LOW IN PROTEIN
- 1 August 1945
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 144 (3) , 464-467
- https://doi.org/10.1152/ajplegacy.1945.144.3.464
Abstract
Cobalt (0.5 mg. Co as cobaltous sulfate daily) produced a polycythemia in rats with a chronic anemia resulting from the feeding of a diet low in protein (3.5% lactalbumin) at approx. the same rate and to about the same degree as in normal stock rats. These results suggest that Co is a sufficiently effective hemopoietic stimulant to produce either a conversion of body tissue protein into Hb protein or an increased utilization of the limited exogenous supply of protein for this purpose.This publication has 3 references indexed in Scilit:
- The Role of Dietary Protein in Hemoglobin FormationJournal of Nutrition, 1943
- The Relation of the Sulphur Amino Acids to the Toxicity of Cobalt and Nickel in the RatJournal of Nutrition, 1942
- ON THE MECHANISM OF THE HEMATOPOIETIC ACTION OF COBALTAmerican Journal of Physiology-Legacy Content, 1935