Isolation and chemical structure of aklanonic acid, an early intermediate in the biosynthesis of anthracyclines.
- 1 January 1985
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 38 (8) , 1034-1039
- https://doi.org/10.7164/antibiotics.38.1034
Abstract
The fermentation, isolation and structure elucidation of aklanonic acid are described. The compound was isolated from fermentations of Streptomyces strain ZIMET 43,717. Aklanonic acid is a yellow-orange crystalline substance, melting at 203 .apprx. 204.degree. C (dec), having the molecular formula C21H16O8, and possessing UV maxima at 258, 282 (sh) and 438 nm (CHCl3). In dimethyl sulfoxide or pyridine aklanonic acid is unstable and a new compound (aklanone) is formed as a conversion product. The elucidation of the structures has shown that aklanonic acid and aklanone are derivatives of 1,8-dihydroxyanthraquinone.This publication has 2 references indexed in Scilit:
- Antitumor anthracycline antibiotics, aclacinomycin A and analogues. II. Structural determination.The Journal of Antibiotics, 1979
- Antibiotika aus actinomyceten. zur chemischen konstitution des antibiotikums griseorhodin ATetrahedron, 1978