Long‐Term Response to Topiramate in Patients with West Syndrome
Open Access
- 1 January 2000
- Vol. 41 (s1) , 91-94
- https://doi.org/10.1111/j.1528-1157.2000.tb02180.x
Abstract
Purpose: The long‐term effectiveness of topiramate (TPM) was evaluated in children with West syndrome previously refractory to antiepileptic drug (AED) therapy. Methods: Children with infantile spasms who completed a pilot study were eligible to enter a long‐term extension phase in which the dosages of TPM and other AEDs could be adjusted to optimal response (maximum, 50 mg/kg/day TPM). The mean duration of long‐term therapy was 18 months in the 11 children who were followed; the mean TPM dosage was 29 mg/kg/day. Results: Eight (73%) children were continuing TPM therapy at the time data were analyzed; four (50%) children were spasm free, seven (88%) had experienced a ges;50% reduction in spasms, and three (38%) were able to achieve TPM mono‐therapy. Conclusions: TPM was well tolerated in that no patients discontinued because of adverse events. The response achieved with TPM during the pilot study was maintained in most children.Keywords
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