MORPHOLOGIC DIFFERENTIATION OF MENNINGO-ENCEPHALITIS OF RABBITS AND EPIDEMIC (LETHARGIC) ENCEPHALITIS
- 1 March 1924
- journal article
- other
- Published by American Medical Association (AMA) in Archives of Neurology & Psychiatry
- Vol. 11 (3) , 321-327
- https://doi.org/10.1001/archneurpsyc.1924.02190330071006
Abstract
Since my observation1that chronic inflammatory processes are commonly found in the central nervous system of rabbits, and that in many cases the condition takes on the form of an epidemic meningoencephalitis, similar findings have been reported from widely separated parts of the world. In England, Twort2found many of his laboratory animals affected. Levaditi3has found similar conditions in France, and in the eastern part of the United States, Flexner4reports the lesions in 50 per cent. of supposedly normal animals. The importance of the condition is obviously in the possibility that these spontaneous lesions in supposedly normal animals may be confused with the result of experimental procedure. It is interesting in this regard to consider some of the experiments which, in the opinion of the investigator concerned, have led to the production of lesions in the central nervous system of the animal. The administrationKeywords
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