Cellular Mechanisms for Lipid Deposition in Atherosclerosis

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Abstract
(Second of Two Parts*)For a tissue to maintain its cholesterol level, each of its cells must have a fairly constant cholesterol pool, and removal of cholesterol must be in equilibrium with input and cell synthesis. Clearly, the cells of the arterial intima that are involved in the atherosclerotic process are not in equilibrium; rather, they are in "positive cholesterol balance," since the pool is expanding, and input plus synthesis is greater than loss. I should like to examine the defects in cellular intake, metabolism and removal of cholesterol that can produce an increasing pool of cholesterol or its . . .