THE TUBERCULOSTATIC ACTION OF THE SODIUM SALTS OF CERTAIN SYNTHETIC ALICYCLIC ACIDS

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Abstract
The bacteriostatic action against tubercle bacilli, strain A27, of certain alicylic acids (acetates and carboxylates of chain cyclo-pentanes and -hexanes) was studied in vitro on cultures in glycerine broth and in Kirch-ner''s medium. So-called in-vivo tests were made by planting 0.2 ml. of cultures exposed 24 hrs. to small concs, of the compounds on chorioallantoic membranes of chick embryos. 4 of the alicylic acids showed a high order of bacteriostatic action in vitro, 7.7 mg. % to 10 mg. % totally inhibiting growth. These same compounds proved similarly effective in reducing the size of lesions occurring on the egg membranes. The Na salt of chaulmoogric acid, studied for comparison, proved to have relatively little bacteriostatic action.