CELL-MEDIATED IMMUNE-RESPONSE TO VIRULENT AND ATTENUATED ANAPLASMA-MARGINALE ADMINISTERED TO CATTLE IN LIVE AND INACTIVATED FORMS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 38  (2) , 173-179
Abstract
The leukocyte migration-inhibition test (LMIT) and lymphocyte transformation of blood leukocytes from cattle exposed to virulent, attenuated and inactivated preparations of A. marginale served as indices of cell-mediated immunity in bovine anaplasmosis. The LMIT response increased markedly in cattle vaccinated with attenuated A. marginale or injected with virulent A. marginale. Cattle inoculated with inactivated anaplasma developed a transient, low-level LMIT response. The response to antigenic stimulation recorded in the lymphocyte transformation test in cattle given live Anaplasma was less than the response in cattle vaccinated with inactivated Anaplasma in adjuvant.