6-(Alkylamino)-9-benzyl-9H-purines. A new class of anticonvulsant agents
- 1 March 1988
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 31 (3) , 606-612
- https://doi.org/10.1021/jm00398a019
Abstract
Several 9-alkyl-6-substituted purines were synthesized and tested for anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats. Most compounds were prepared in three steps from 5-amino-4,6-dichloropyrimidine or in two steps via alkylation of 6-chloropurine. Potent anticonvulsant activity against MES resided in compounds that contain a benzyl substituent at the 9-position of 6-(methylamino)- or 6-(dimethylamino)purine. Among commonly used agents for control of seizures, this type of structure represents a new class of potent anticonvulsant agents.This publication has 1 reference indexed in Scilit:
- Enzyme inhibitors. XIX. Synthesis of some 1-hydroxy-2-hydroxymethyl-4-(6)substituted-9-purinyl)cyclohexanes as nucleoside analogsJournal of Medicinal Chemistry, 1968