PENTACHLOROPHENOL POISONING

  • 1 January 1983
    • journal article
    • research article
    • Vol. 25  (7) , 527-530
Abstract
Pentachlorophenol (PCP) is a pesticide commonly used as a wood preservative. Although exposure has been well controlled in large chemical manufacturing plants, overexposures have recently become a concern at smaller facilities. Five cases of PCP poisoning, including 2 fatalities, occurred in 2 small wood preservative plants. All cases had fever, including severe hyperpyrexia in 2; an increased anion gap and renal insufficiency were noted in 2 others. PCP may uncouple oxidative phosphorylation, resulting in a poisoning syndrome characterized by hyperpyrexia, diaphoresis, tachycardia, tachypnea, abdominal pain, nausea and even death.

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