Uveal Extraction and Clearance of Oxygen in Normal, Inflamed and Hyperthermic Eyes

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Abstract
Measurements of O2 extraction and clearance by the uvea in vivo are based upon measurements of arteriovenous O2 differences and of aqueous humor O2 concentrations and rates of flow in the dog. The mean extraction of O2 in normal eyes was 0. 25 mm3 O2/ml plasma. This is approximately doubled by mild hyperthermia and halved by severe uveitis, as were extraction ratios. Uveal O2 clearance/hr. in normal eyes is equivalent to O2 dissolved in 061 ml of arterial plasma. This is the basis for a computed blood flow of 0. 42 ml/g of wet, total uvea/min., which generally supports high flow values obtained by other techniques. Carbon dioxide production as measured by uveal AV [arteriovenous] differences, far exceeds the values for O2 extraction and implies that a non-oxidative scheme of respiration prevails in uveal and anterior segment tissues.

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