Induction of the Early Growth Response 1 Gene by Epstein-Barr Virus Lytic Transactivator Zta
Open Access
- 1 August 2006
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 80 (15) , 7748-7755
- https://doi.org/10.1128/jvi.02608-05
Abstract
Early growth response 1 (Egr-1) is a cellular transcription factor involved in diverse biologic functions. Egr-1 has been associated with Epstein-Barr virus (EBV) infection, but it is still unknown whether any EBV protein regulates Egr-1 expression. In this study, we first showed that EBV reactivation is involved in upregulation of Egr-1 and that Egr-1 can be induced by Zta, an EBV lytic transactivator. Zta not only binds to the Egr-1 promoter but also activates the ERK signaling pathway to trigger binding of Elk-1 to the Egr-1 promoter. In addition, knockdown of Egr-1 significantly reduces the spontaneous expression of Zta and Rta in EBV-infected 293 cells, suggesting that a positive-feedback network involving Egr-1 is required for EBV reactivation. This study also implies that Zta has the potential to affect expression of certain genes through Egr-1.Keywords
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