Immunohistochemical determination of tumour growth fraction in human ovarian carcinoma

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Abstract
The proportion of proliferating tumour cells in a tumour (''growth fraction'') was estimated in 30 patients with primary ovarian carcinoma, using monoclonal antibody Ki-67 which reacts with a nuclear antigen present only in proliferating cells. A positive correlation between the ''growth fraction'' and both the clinical stage and histological grade of the tumours was observed. A high ''growth fraction'' was observed in advanced, metastastic and poorly differentiated tumours and a low ''growth fraction'' with early stage, well-differentiated tumours. This information which has not been available previously to clinicians may be of practical value for determining the prognosis, and influencing treatment recommendation.