Immunonephelometric Quantitation of Complement Split Product (C3d) Plasma Levels in Rheumatic Disease
- 1 January 1985
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Rheumatology
- Vol. 14 (4) , 421-426
- https://doi.org/10.3109/03009748509102048
Abstract
A simple method is described for routine quantitative determination of C3d by laser nephelometry after precipitation of intact C3 by polyethylene glycol. Plasmas from 292 patients with different types of rheumatic disease was tested. Elevated C3d levels were a far more common finding than low levels of complement components C3 or C4, but despite the increased sensitivity, the test only seemed diagnostically useful for systemic lupus erythematosus and MCTD. Though a better test than the quantitation of C3 and C4, the value of C3d determination in rheumatic disease seems to be limited.Keywords
This publication has 15 references indexed in Scilit:
- Plasma C3d/C3 quotient as a parameter for in vivo complement activationJournal of Immunological Methods, 1984
- A simple method for quantitative measurement of C3d in human plasmaJournal of Immunological Methods, 1984
- The use of C3d as a means of monitoring clinical activity in systemic lupus erythematosus and rheumatoid arthritis.Annals of the Rheumatic Diseases, 1983
- Influence of molecular size of IgA on its immunoassay by various techniques. III. ImmunonephelometryJournal of Immunological Methods, 1982
- Measurement of the complement C3 breakdown product C3d by rocket immunoelectrophoresisJournal of Immunological Methods, 1982
- A PEG-precipitation laser nephelometer technique for detection and characterization of circulating immune complexes in human seraJournal of Immunological Methods, 1981
- Double-decker rocket immunoelectrophoresis for direct quantitation of complement C3 split products with C3d specificities in plasmaJournal of Immunological Methods, 1981
- Clinical applications of complement measurements in rheumatic diseasesThe Lancet Healthy Longevity, 1975
- Hypocomplementemia in rheumatoid arthritisThe American Journal of Medicine, 1973
- Studies on the Depressed Hemolytic Complement Activity of Synovial Fluid in Adult Rheumatoid ArthritisActa Rheumatologica Scandinavica, 1963