SOME EFFECTS OF d-TUBOCURARINE ON OXIDATIONS IN MAMMALIAN TISSUES

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Abstract
Standard manometric techniques were used to measure rates of consumption on strips of the sternohyoid muscle of dog and rat, pieces of diaphragm of the rat, minces of the sternohyoid muscle of the dog, gastro-cnemius muscle of the rat and guinea pig, and hashed brain of the rat. Minces of rat and guinea pig gastrocnemius and dog sternohyoid muscles consumed significantly greater amts. of O2 than controls following the in vivo admn. of d-tubocurarine, but not following the in vitro addition of the compound in the reaction vessels. The greater O2 consumption was noted regardless of the presence of added pyruvate as substrate, but, when present, greater amts. of pyruvate were utilized. O2 consumption of strips of dog and rat sternohyoid muscles and pieces of rat diaphragm, which approach more closely the natural physiological state, was not altered significantly by d-turbocurarine in vivo or in vitro. Cyclopropane anesthesia, Ca ions, and anoxia were eliminated as factors in the responses obtained. It seems probable that d-tubocurarine, in doses sufficient to paralyze respiration, has no toxic effect on the oxidative reactions in intact muscles or brain.

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