Antihistaminic Drugs

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Abstract
IN 1937, Bovet and Staub1 demonstrated that certain phenolic ethers were able to block the effect of histamine. The most active of this series was 2-isopropyl-5-methylphenoxy-ethyldiethylamine (929 F). Study of another series of compounds, chemically allied to 929 F, showed that N-phenyl-N-ethyl-N1-diethylethylenediamine (1571 F) antagonized a variety of responses to histamine but still was toxic.2 It was noted that, among the drugs studied, toxicity did not necessarily parallel antihistaminic activity, a point that encouraged further investigation. The first histamine antagonist to have high activity and relatively low toxicity was 2339 RP, or antergan, which was described by Halpern3 in 1942 . . .