The Effects of Adenosine Upon the Coronary Circulation Studied by Thermography. An Experimental Study

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Abstract
If blood passes through extracorporeal circuits, platelets are activated even if the patient is fully heparinized.1 These activated thrombocytes begin to adhere, cluster, release their granular constituents, and within minutes of the institution of cardio pulmonary bypass a sheath of platelet and fibrin aggregates will line all components of the extracorporeal circuit.2,3,4 This process endangers the patient in two ways: (1) The lining of aggregates on the "down side" to the arterial filter may fragment and cause a shower of microemboli. (2) Intra-bypass platelet aggregation depletes the number of circulating thrombocytes, thus increases the possibility of post-operative bleeding.5,6,7