Feline Oncornavirus—Associated Cell Membrane Antigen: Expression in Transformed Nonproducer Mink Cells

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Abstract
The feline oncornavirus-associated cell membrane antigen (FOCMA) is a target for naturally occurring immunity that protects the cat against development of fibrosarcoma and leukemia. Feline sarcoma virus-transformed "nonproducer" mink cells express high levels of FOCMA, but not of the major viral structural proteins. Transformation of the same cells by murine sarcoma virus, or infection with feline leukemia virus, which is nontransforming for epithelial or fibroblastic cells, did not induce FOCMA. Thus, FOCMA expression in mink lung cells is specifically associated with transformation by feline sarcoma virus.