In-Hospital Mortality Following Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Abstract
CHRONIC OBSTRUCTIVE pulmonary disease (COPD) results in substantial morbidity and mortality. Patients with COPD experience acute exacerbations or "flares" characterized by increased dyspnea, sputum production, and/or sputum purulence. These exacerbations result in approximately 500 000 hospitalizations annually in the United States1 and are most often precipitated by respiratory tract infections, congestive heart failure, arrhythmias, or unidentified causes.2 Exacerbation of COPD is the fourth leading cause of death3 and represents a significant health burden for the US population.

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