Use of 5-Fluorocytosine in Patients with Impaired Renal Function
- 17 November 1973
- Vol. 4 (5889) , 382-384
- https://doi.org/10.1136/bmj.4.5889.382
Abstract
The plasma level and elimination of 5-fluorocytosine (5-FC) was measured in normal subjects and patients with impaired renal function. Prolongation of the half-life of the drug in renal failure has been confirmed. Renal clearance of 5-FC was about 75% of the creatinine clearance and a corresponding modification of drug dosage should be made in patients with renal insufficiency.Keywords
This publication has 3 references indexed in Scilit:
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- The Kinetics of 5-Fluorocytosine Elimination in ManAustralian and New Zealand Journal of Medicine, 1972
- The metabolism of 5-fluorocytosine-214C and of cytosine-14C in the rat and the disposition of 5-fluorocytosine-214C in manBiochemical Pharmacology, 1966