Zinc, Copper, Magnesium, and Calcium in Blood and Plasma after Phlebotomy

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Abstract
Zn levels in plasma and whole blood were investigated in 2 groups of blood donors. The 1st group consisted of 19 men and 11 women who donated blood for the 1st time and were followed during 3 phlebotomies. The 2nd group comprised 44 men with 9 or more previous blood donations, their blood being analyzed on a single occasion. Plasma concentrations of Cu, Mg, Ca and ferritin were also analyzed. The Zn levels in whole blood and plasma in the 2nd group were significantly lower as compared to the 1st group (P < 0.001). Furthermore, the 2nd group had significantly higher levels of copper and Cu:Zn quotient in plasma as compared to those of the new blood donors (P < 0.001). Besides the earlier known effect of blood donation on Fe stores, there are also signs of Zn depletion when judged from the Zn levels in plasma and in erythrocytes. No significant changes in Ca and Mg concentrations were seen during phlebotomy.

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