Influence of thiocompounds on the metabolism of N-nitrosodiethylamine
- 31 December 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 9 (7) , 1303-1306
- https://doi.org/10.1093/carcin/9.7.1303
Abstract
Diethyldithiocarbaminate (DDTC), mercaptoethanesulfonate (MESNA) and ethylxanthate (PEX) were tested for their influence on N-nitrosodiethylamine (NDEA) metabolism. The exhalation rate of 14CO2 released from [14C]NDEA was decreased by PEX, but not by MESNA or DDTC. The sulfur compounds led to an increased excretion of unchanged NDEA in urine in the order PEX > DDTC > > MESNA. The activity of NDEA-deethylase in liver microsomal system was decreased only after DDTC or PEX treatment. Glutathione content and glutathione-S-transferase activity were not affected significantly by any of the tested compounds. NDEA-induced single-strand breaks in liver cell DNA were inhibited after PEX treatment.This publication has 12 references indexed in Scilit:
- Influence of a prolonged treatment with disulfiram andd(-)penicillamine on nitrosodiethylamine-induced biological and biochemical effects in ratsZeitschrift für Krebsforschung und Klinische Onkologie, 1985
- Reduced glutathione inhibits the alkylation by n-nitrosodimethylamine of liver DNA in vivo and microsomal fraction in vitroChemico-Biological Interactions, 1985
- Effects of disulfiram on the metabolism of nitrosodiethylamine during liver carcinogenesisZeitschrift für Krebsforschung und Klinische Onkologie, 1984
- Delay of bladder cancer induction in rats treated with N-nitroso-N-butyl-N-(4-hydroxybutyl)amine by administration of sodium-2-mercaptoethanesulfonate (Mesna)Cancer Letters, 1984
- Effects of disulfiram on mixed function oxidase system and trace element concentration in the liver of ratsBiochemical Pharmacology, 1982
- Fluoro-substituted N-nitrosamines. 2. Metabolism of N-nitrosodiethylamine and of fluorinated analogs in liver microsomal fractionsCarcinogenesis: Integrative Cancer Research, 1982
- Effect of disulfiram on the alkylation of rat liver DNA by nitrosodiethylamineZeitschrift für Krebsforschung und Klinische Onkologie, 1980
- Inhibition of Dimethylnitrosamine-Induced Strand Breaks in Liver DNA and Liver Cell Necrosis by Diethyldithiocarbamate 2JNCI Journal of the National Cancer Institute, 1977
- Influence of disulfiram on the organotropy of the carcinogenic effect of dimethylnitrosamine and diethylnitrosamine in ratsZeitschrift für Krebsforschung und Klinische Onkologie, 1976
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951