Enantiomeric Separation by Cyclodextrin-Modified Micellar Electrokinetic Chromatography Using Bile Salt

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Abstract
A method for enantiomeric separation by cyclodextrin-modified micellar electrokinetic chromatography (MEKC) with bile salt micelles is described. The enantiomeric resolution was achieved with a mixed sodium taurodeoxycholate (TDC)-β-cyclodextrin (CD) solution (pH 7–9) utilizing a bare capillary. In sodium dodecyl sulfate (SDS)-CD solutions, similar result were not obtained. The effect of varying concentrations of TCD and β-CD and pH on the selectivity and resolution were also briefly investigated.