Motesanib Diphosphate in Progressive Differentiated Thyroid Cancer
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Open Access
- 3 July 2008
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 359 (1) , 31-42
- https://doi.org/10.1056/nejmoa075853
Abstract
The expression of vascular endothelial growth factor (VEGF) is characteristic of differentiated thyroid cancer and is associated with aggressive tumor behavior and a poor clinical outcome. Motesanib diphosphate (AMG 706) is a novel oral inhibitor of VEGF receptors, platelet-derived growth-factor receptor, and KIT.Keywords
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