Electron Spin Resonance of X-Irradiated Nucleic Acid Base Pairs, 1-Methyl Cytosine:5-Fluorouracil at 300 K

1 February 1978

journal article
research article
Published by JSTOR in Radiation Research

Vol. 73 (2) , 212-220
https://doi.org/10.2307/3574815

Abstract

Three free radicals were detected in single crystals of a molecular complex between 1-methylcytosine (1MeC) and 5-fluorouracil (5FU) X-irradiated and observed by ESR at 77.degree. K. One of these (Radical I), formed by H abstraction from N(1) of 5FU, disappears when the crystal is warmed to 220.degree. K. The other 2 radicals are stable at room temperature. Radical II is formed by H addition to C(6) of 5FU. Radical III was tentatively assigned to a radical formed by H addition to the oxygen on C(4) of 5FU. Structural analysis of these 2 stable room-temperature radicals and the resulting implication that free radical damage may be transferred from 1MeC to 5FU are discussed.

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