Contrasts between pindolol and propranolol concentration‐response relationships.

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Abstract
The plasma concentration‐response relationships of oral and intravenous pindolol and propranolol have been studied in a group of eight healthy male subjects who received each dosage form in a randomized single‐ blind cross‐over manner. Despite similar elimination half‐lives, the duration of action of pindolol was longer than that of propranolol. This longer duration of action was associated with a flatter concentration‐response curve for pindolol and may be related to the partial agonist activity of pindolol. Propranolol concentration‐ response curves were dependent on the route of drug administration whereas pindolol curves were similar following oral and intravenous routes of administration.