Murine cytotoxic T-cell response to alphavirus is associated mainly withH- 2D k

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Abstract
A secondary in vitro response to alphaviruses Bebaru, Sindbis, and Semliki Forest is described. Optimum response appears at day 5–6 of culture. The cells responsible for lytic activity are nonadherent, Φ-positive, Ig−, and mainly Ly-2.1 positive. Out of five haplotypes tested (H- 2 d ,H- 2 b ,H- 2 s ,H- 2 q , andH- 2 k ) onlyH- 2 k was a responder. Genetic mapping of the response located it solely in theD region of theH- 2 complex. The other four haplotypes responded with a high antiself activity after a second stimulation with viruses. This antiself response also maps in theD region of theH- 2 complex. No complementation was observed in F1 hybrids between responder and nonresponder strains.

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