DNA — Structure and Enzymatic Synthesis

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Abstract
IN the past ten years there has been a phenomenal increase in knowledge of the mechanism of synthesis of deoxyribonucleic acid (DNA) in bacterial, mammalian and virus–infected cell systems. The introduction of new technics and instrumentation has led to further eludication of DNA structure and physical properties, and essentially complete confirmation of the double-helical model of DNA proposed by Watson and Crick thirteen years ago.1 Investigations of the interrelations among the 3 major biologic macromolecules, the so-called "holy trinity," — consisting of DNA, ribonucleic acid (RNA) and protein, — have partially answered fundamental questions concerning gene structure, replication, and mutation . . .