Preferential virological response to interferon-α 2a in patients with chronic hepatitis C infected by virus genotype 3a and exhibiting a lowγ-GT/ALT ratio

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Abstract
Hepatitis C virus infection causes acute and often chronic hepatitis. Therapy with interferon-α has been shown to induce remission of the inflammatory process within the liver and also elimination of the virus. However, only about 50% of treated patients respond in terms of at least a transient disappearance of viral RNA from the circulation below the limit of detection. In order to find prognostic factors for responsiveness, patients with chronic hepatitis C virus infection were analyzed for virus genotype and pretreatment biochemical liver parameters including serum AST, ALT, andγ-GT activities. Whereas the initial biochemical response to interferon-α 2a was found not to be related to virus genotype, the initial virological response was found to be closely related to infection by genotype 3a and to a low pretreatment ratio of serumγ-GT/ALT activity. These data confirm and extend the importance of virus genotype for responsiveness to interferon-α therapy and introduce an additional, host-specific parameter with a potential predictive value, namely the pretreatment ratio of serumγ-GT/ALT activity.