A simple procedure for obtaining high‐quality nmr spectra of semiquantitative value from small tissue specimens: cervical biopsies.
- 1 October 1992
- journal article
- other
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 27 (2) , 349-355
- https://doi.org/10.1002/mrm.1910270215
Abstract
The handling of small tissue biopsy samples (<100 μl) for NMR investigations poses special problems. Optimal and stable positioning of the samples within the sensitive volume of the radiopfrequency coil can be achieved by inserting the sample in a capillary. Methods for quantitation of the spectral information from samples requiring histological evaluation after the NMR experiment are discussed, in particular with respect to cervical biopsies.Keywords
This publication has 7 references indexed in Scilit:
- Locoregional administration of 5-fluoro-2′-deoxyuridine (FdUrd) in Novikoff hepatoma in the rat: effects of dose and infusion time on tumor growth and on FdUrd metabolite levels in tumor tissue as determined by19F-NMR spectroscopyZeitschrift für Krebsforschung und Klinische Onkologie, 1991
- Uterine cervical punch biopsy specimens can be analyzed by 1h mrsMagnetic Resonance in Medicine, 1990
- Further evidence that the narrow 1H magnetic resonance signals from malignant cells do not arise from intracellular lipid dropletsNMR in Biomedicine, 1989
- Observer variation in histopathological diagnosis and grading of cervical intraepithelial neoplasia.BMJ, 1989
- Chain‐Fluorinated polyamines as tumour markers. iii. determination of geminal difluoropolyamines and their precursor 2,2‐difluoroputrescine in normal tissues and experimental tumours byin vitroandin vivo19f NMR spectroscopyNMR in Biomedicine, 1988
- CLASSIFICATION OF HUMAN TUMOURS BY HIGH-RESOLUTION MAGNETIC RESONANCE SPECTROSCOPYThe Lancet, 1986