Chemistry of Sponges. 19. Novel Bioactive Metabolites from Hamigera tarangaensis
- 1 December 1999
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 63 (1) , 79-85
- https://doi.org/10.1021/np9903494
Abstract
Seven new compounds (1−6 and 10) with a unique carbon skeleton have been isolated from the sponge Hamigera tarangaensis, and the structure of a previously reported metabolite has been revised from 12 to 8. The structures have been assigned from extensive NMR examination. Compounds 3−6 showed moderate in-vitro cytotoxicity against P-388, while 3 showed 100% in-vitro virus inhibition against both the Herpes and Polio viruses, with only slight cytotoxicity.Keywords
This publication has 16 references indexed in Scilit:
- Dilemmaones A−C, Unusual Indole Alkaloids from a Mixed Collection of South African SpongesJournal of Natural Products, 1998
- Phorboxazoles A and B: potent cytostatic macrolides from marine sponge Phorbas speciesJournal of the American Chemical Society, 1995
- Chemistry of Sponges, 17. A Novel Brominated Benzocylooctane Derivative from Hamigera taragensisJournal of Natural Products, 1995
- Four New Dimeric Peptide Alkaloids, Anchinopeptolides B-D, and Cycloanchinopeptolide C, Congeners of Anchinopeptolide A, from the Mediterranean Marine Sponge Anchinoe tenaciorJournal of Natural Products, 1994
- Antiviral and antitumor agents from a New Zealand sponge, Mycale sp. 2. Structures and solution conformations of mycalamides A and BThe Journal of Organic Chemistry, 1990
- Ptilomycalin A: a novel polycyclic guanidine alkaloid of marine originJournal of the American Chemical Society, 1989
- Discorhabdin D, an antitumor alkaloid from the sponges Latrunculia brevis and Prianos spThe Journal of Organic Chemistry, 1988
- Mycalamide A, an antiviral compound from a New Zealand sponge of the genus MycaleJournal of the American Chemical Society, 1988
- Discorhabdin C, a highly cytotoxic pigment from a sponge of the genus LatrunculiaThe Journal of Organic Chemistry, 1986
- An organic chemical model of the acyl-.alpha.-chymotrypsin intermediateJournal of the American Chemical Society, 1984