The Absorption Spectrum of Cholesterol and its Biological Significance with Reference to Vitamin D. Part I

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Abstract
Cholesterol from cod liver oil or brain (m.p. 148.5[degree]) exhibits absorption bands at 293, 280 and 269[mu][mu]. Fractional crystallization results in a 4-fold increase in the intensity of these bands when the least soluble fraction is examined. Irradiation of the cholesterol causes disappearance of the selective absorption and feeding tests show that the material becomes strongly anti-rachitic, the least soluble fraction being 4 times as active as the original cholesterol. It is concluded that the selective absorption is due to an impurity in cholesterol which must be very closely connected with the vitamin D precursor.

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