An Efficient and Fast Procedure for the Hantzsch Dihydropyridine Synthesis under Microwave Conditions

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Abstract
A single-mode microwave cavity synthesizer with temperature and pressure control was used to accelerate the Hantzsch synthesis of 4-aryl and 4-alkyl-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylates. In comparison with both conventional methods and microwave-assisted reactions performed in a domestic microwave oven, shorter reaction times and higher yields were obtained. The improved yields under microwave conditions made it possible to synthesize a small library, with acceptable purity.

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