INVESTIGATIONS ON THE EFFECT OF THYROID PREPARATIONS AND OF METHYLTHIOURACIL ON THE ADRENAL GLANDS AND CHEMISTRY, AS WELL AS ON SOME OTHER ORGANS

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Abstract
7-8 month-eld male white rats were given thyroid extract (100 mg./day) or 20-30 mg. of methyl-thiouracil. Thyroid admn. caused an increase of adrenal wt. of 61% (per 100 g. body wt.); "adrenaline" (v.Euler and Hamberg, 1949) rose by 88%; ascorbic acid by 330% and cholesterol by 85%. The heart wt. increased 54%. Methylthiouracil caused a 23% decrease in adrenal wt.; "adrenaline" increased 53%; ascorbic acid 76%; and cholesterol fell 29%. Liver glycogen was absent in both groups. Thyroid increases medullary and cortical activity; methylthiouracil increases medullary but decreases cortical activity.