Neonatal Blood Pressure and Salt Taste Responsiveness
- 1 September 2002
- journal article
- research article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 40 (3) , 280-285
- https://doi.org/10.1161/01.hyp.0000029973.76439.ab
Abstract
To test the association between neonatal blood pressure (BP) and salt taste response, 283 healthy hospitalized neonates were administered small drops (0.06 mL) of water and 0.1 molar (mol/L) and 0.3 mol/L NaCl solutions by means of cannulas through a nipple with a pressure transducer to record sucking responses. Neonatal and 1-month BPs were recorded by ultrasound. Mean number of sucks per burst was scored as “aversive” if the 0.3 mol/L salt minus water difference score was ≤−10 mean sucks per burst, “preferential” if this difference was >0, and “neutral” otherwise. Babies with “preferential” responses had higher diastolic BPs than those with neutral (1.9 mm Hg) or aversive responses (3.1 mm Hg) ( P trend=0.05). After adjustment for age, gender, birth weight, and activity for babies with at least one grandparent receiving antihypertensive medication, mean adjusted systolic pressure was 6.7 mm Hg higher ( P =0.003) ( P trend=0.003) and mean adjusted diastolic pressure was 5.0 mm Hg higher ( P =0.010) ( P trend=0.011) in neonates with preferential versus aversive salt taste responses. There was no relation of BP to sucking responses to sweet (sucrose) stimuli. Neonates can distinguish between dilute salt solutions and water. This response is related to BP and might be a potential risk factor for high BP later in life.Keywords
This publication has 29 references indexed in Scilit:
- Initiation of hypertension in utero and its amplification throughout life.BMJ, 1993
- Salt level in weaning diet affects saline preference and fluid intake in Dahl rats.Hypertension, 1986
- Developmental changes in salt acceptability in human infantsDevelopmental Psychobiology, 1986
- Longitudinal study of salt preferences in normotensive and hypertensive rats.Hypertension, 1985
- The active ion transport properties of canine lingual epithelia in vitro. Implications for gustatory transduction.The Journal of general physiology, 1984
- Neonates' heart rate, sucking rhythm, and sucking amplitude as a function of the sweet tasteJournal of Experimental Child Psychology, 1980
- Cardiovascular response to mental stress in normal adolescents with hypertensive parents. Hemodynamics and mental stress in adolescents.Hypertension, 1979
- Taste perception in the newborn infantInfant Behavior and Development, 1978
- The stability and interrelationships of newborn sucking and heart rateDevelopmental Psychobiology, 1976
- Ingestive responses of human newborns to salty, sour, and bitter stimuli.Journal of Comparative and Physiological Psychology, 1975