Mutations Affecting Iron Transport in Escherichia coli

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Abstract
A mutant of Escherichia coli K-12 unable to form an essential component of the enterochelin-dependent iron transport system has been isolated. This strain carries a mutation in a gene designated fep , mapping close to two genes, entA and entD , concerned with enterochelin synthesis. Strain AN102, which carries the fep − allele, accumulates large quantities of enterochelin and gives a growth response to sodium citrate. The cytochrome b 1 and total iron content, and the measurement of the uptake of 55 Fe 3+ , indicate an impairment of the enterochelin-dependent iron transport system. The growth response to sodium citrate is related to the presence, in strain AN102, of an inducible citrate-dependent iron transport system.

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