Using One- and Two-Dimensional NMR Techniques to Characterize Reaction Products Bound to Chiron SynPhase Crowns
- 9 February 2000
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Combinatorial Chemistry
- Vol. 2 (2) , 127-133
- https://doi.org/10.1021/cc9900551
Abstract
Solid-phase MAS techniques have proved to be very useful in characterizing compounds bound to resin; however, little has been reported on using NMR to characterize compounds attached to Chiron SynPhase crowns. We have used proton, carbon, and COSY spectra obtained with a Varian Nano•nmr probe to characterize products from a published reaction sequence attached to MD (methacrylic acid/dimethylacryl-amide copolymer) crowns. We have also performed solvent surveys to determine the best solvents for acquiring spectra of materials bound to both MD and PS (polystyrene) crowns.Keywords
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