G6PD Vientiane: A new glucose-6-phosphate dehydrogenase variant with increased stability
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 43 (1) , 85-89
- https://doi.org/10.1007/bf00396482
Abstract
A new G6PD variant, called G6PD Vientiane, has been discovered in a patient from Laos. The characteristics of this variant are: mild enzyme deficiency (about 50% of the normal activity) in the granulocytes and the red cells, with normal G6PD-related antigen concentration; increased stability; normal Km glucose 6-phosphate and NADP+; increased inhibition constant by NADPH; decreased inhibition by ATP; slightly increased utilization of the substrate analogue; abnormal pH curve, with maximum activity at pH 9.5; slightly reduced starch gel electrophoretic migration. The implications of the molecular stability of a deficient mutant variant are discussed.This publication has 19 references indexed in Scilit:
- G6PD VariantsPublished by Springer Nature ,1978
- Hereditary erythrocyte pyruvate kinase deficiency: molecular and functional studies of four mutant PK variants detected in SpainClinica Chimica Acta; International Journal of Clinical Chemistry, 1977
- Human erythrocyte pyruvate kinase Total purification and evidence for its antigenic identity with L-type enzymeBiochimica et Biophysica Acta (BBA) - Enzymology, 1977
- A spanish family with erythrocyte pyruvate kinase deficiency: Contribution of various immunologic methods in the study of the mutant enzymeClinica Chimica Acta; International Journal of Clinical Chemistry, 1977
- Human erythrocyte phosphoglycerate kinase deficiency: Presence in a deficient patient of a stable variant with lowered catalytic activityClinica Chimica Acta; International Journal of Clinical Chemistry, 1976
- Gd (−) Matam, an african glucose-6-phosphate dehydrogenase variant with enzyme deficiency. Biochemical and immunological properties in various hemopoietic tissuesClinica Chimica Acta; International Journal of Clinical Chemistry, 1975
- Human glucose-6-phosphate dehydrogenase variants: a supplementary tabulationAnnals of Human Genetics, 1973
- Hemolytic Anemia and G6PD DeficiencyScience, 1973
- Comportement immunologique de la glucose-6-phosphate-deshydrogenase érythrocytaire chez des mutants déficientsClinica Chimica Acta; International Journal of Clinical Chemistry, 1970
- In vivo lability of glucose-6-phosphate dehydrogenase in GdA- and Gdmediterranean deficiencyJournal of Clinical Investigation, 1968