Mechanistic Insights into Cu-Catalyzed Asymmetric Aldol Reactions: Chemical and Spectroscopic Evidence for a Metalloenolate Intermediate
- 4 December 1998
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 37 (22) , 3124-3126
- https://doi.org/10.1002/(sici)1521-3773(19981204)37:22<3124::aid-anie3124>3.0.co;2-1
Abstract
In situ IR spectroscopy and transmetalation experiments confirm a postulated catalytic cycle. The metalloenolate 1 describes the active intermediate in the aldol reaction catalyzed by [CuF2{(S)-tol-binap}] (see reaction scheme). (S)-tol-binap=(S)-(−)-2,2′-bis(di-p-tolylphosphanyl)-1,1′-binaphthyl.This publication has 0 references indexed in Scilit: