The N‐ethylmaleimide‐sensitive fusion protein (NSF) is preferentially expressed in the nervous system
- 20 June 1994
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 347 (1) , 55-58
- https://doi.org/10.1016/0014-5793(94)00505-2
Abstract
NSF and SNAPs (soluble NSF attachment proteins), originally identified as cytosolic components of intracellular vesicular transport mechanisms, have recently been implicated in Ca2+‐triggered neurotransmitter release from synaptic terminals. Here, we have investigated the temporal and spatial expression pattern of the rodent NSF and SNAP genes. A single transcript of 4.5 kb is highly expressed in rat brain, whereas only minor amounts of NSF mRNA are found in liver, kidney, heart, lung and skeletal muscle. In situ hybridisation revealed NSF transcripts as early as embryonic day 10 preferentially in the nervous system of mouse embryos. In the adult brain NSF is widely expressed with particularly high levels in the hippocampus. An identical expression profile was observed for α/β‐SNAP. Our data are consistent with a central function of NSF and SNAPs in neurotransmission.Keywords
This publication has 17 references indexed in Scilit:
- Synaptic vesicle exocytosis: Molecules and modelsCell, 1994
- A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusionCell, 1993
- Inhibition of axonal growth by SNAP-25 antisense oligonucleotides in vitro and in vivoNature, 1993
- SNAP family of NSF attachment proteins includes a brain-specific isoformNature, 1993
- SNAP receptors implicated in vesicle targeting and fusionNature, 1993
- A Collection of cDNA Clones with Specific Expression Patterns in Mouse BrainEuropean Journal of Neuroscience, 1990
- SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in animals and yeastPublished by Elsevier ,1990
- Neurogenesis in spinal cord of mouse: an autoradiographic analysisBrain Research, 1978
- An investigation of the foetal rat spinal cordCell and tissue research, 1975
- A morphological investigation of an early reflex pathway in developing rat spinal cordJournal of Comparative Neurology, 1973