Genomic structure and complete sequence of the human FGFR4 gene
- 1 February 1998
- journal article
- research article
- Published by Springer Nature in Mammalian Genome
- Vol. 9 (2) , 131-135
- https://doi.org/10.1007/s003359900703
Abstract
We report the genomic structure and entire sequence of the fibroblast growth factor receptor 4 (FGFR4) gene. The gene spans approximately 11.3 kb. It is composed of 18 exons ranging in size from 71 bp to 600 bp. Exon-intron boundaries follow the GT/AG rule. Exon 1 is untranslated and preceded by structural elements characteristic of a TATA-free promoter. Although there are promoter motifs in intron 4 as well, there is currently no evidence of alternative transcription of FGFR4. Comparison of exon-intron boundaries of FGFR4 with those of FGFR1 and 3 reveals a remarkable degree of homology. With the exception of four, exon boundaries are at identical positions in all three receptor genes. Short tandem repeat polymorphisms (STRPs) were identified in introns 2 and 16 of FGFR4. The STRPs together with the sequence information will facilitate the rapid analysis of FGFR4 in those human disorders in which this gene can be considered a candidate.Keywords
This publication has 35 references indexed in Scilit:
- FGFR activation in skeletal disorders: Too much of a good thingTrends in Genetics, 1997
- Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8pCytogenetic and Genome Research, 1995
- The ins and outs of fibroblast growth factorsCell, 1994
- A novel form of FGF receptor‐3 using an alternative exon in the immunoglobulin domain IIIFEBS Letters, 1993
- Newly recognized autosomal dominant disorder with craniosynostosisAmerican Journal of Medical Genetics, 1993
- A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter receptor genes on the distal region of the long arm of chromosome 5Genomics, 1992
- BEK, a receptor for multiple members of the fibroblast growth factor (FGF) family, maps to human chromosome 10q25.3→q26Cytogenetic and Genome Research, 1992
- A gene encoding a fibroblast growth factor receptor isolated from the Huntington disease gene region of human chromosome 4Genomics, 1991
- Transcription from a TATA-less promoter requires a multisubunit TFIID complex.Genes & Development, 1991
- Assignment by in situ hybridization of a fibroblast growth factor receptor gene to human chromosome band 10q26Human Genetics, 1991