Relation between iron stores and non-insulin dependent diabetes in men: case-control study

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Abstract
We tested the hypothesis that the accumulation of iron in the body predicts the development of non-insulin dependent diabetes. We followed 1038 randomly selected men from eastern Finland aged 42-60 for four years; there is a high incidence of non-insulin dependent diabetes in eastern Finland. Fifty three men who were found to have diabetes at baseline (fasting blood glucose concentration ≥6.0 mmol/l or who were already receiving treatment for diabetes) were excluded. This low cut off point for fasting blood glucose was used to increase the sensitivity of the exclusion of participants so that all potential participants who had diabetes or who could have been classed as prediabetic were excluded.