Immunoglobulin (Gm and Km) allotypes in two populations of Catalonia (Spain)

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Abstract
Serum samples from two populations of Catalonia, Spain, 208 from Olot (Gerona) and 209 from Tortosa (Tarragona), were typed for G1m (1, 2, 3, 17), G3m (5, 10, 11, 13, 14, 15, 16, 26), and Km (1). The Gm patterns of the Catalonian populations are characterized by the presence of four haplotypes, Gm 1, 17;21, 26 Gm 1, 2, 17;21, 26 Gm 1, 3;5, 10, 11, 13, 14, 26 and Gm 3;5, 10, 11, 13, 14, 26. The homogeneity for haplotype Gm 1, 17;21, 26 among our data and other European populations suggests the existence of an isofrequency line which starts from the Mediterranean zone of Iberian Peninsula and continues through the northwestern part of Europe. From this line a decreasing cline towards the south can be observed. For the haplotype Gm 1, 2, 17;21, 26, affinities are observed between Catalonian populations and other populations from central Europe. This confirms the existence of a gradient towards low values from NW to SE. The presence of the typical Mongoloid haplotype Gm 1, 3;5, 10, 11, 13, 14, 26 is discussed in this paper. No significant differences in the frequencies of the Km1 allele were observed among the European populations.