Complement and Fc Receptors on Cord Blood and Adult Neutrophils

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Abstract
Summary: The percentage of neutrophils forming erythrocyte-antibody-complement complex (EAC) and with erythrocyte-antibody complex (EAG) was determined for 30 normal newborns and 10 normal adults. The cord values ranged from 84–100% EAC binding cells with a mean of 95%. The adult values ranged from 89–100% EAG binding cells with a mean of 96% rosetted neutrophils. The mean percentage of EAG binding cells in the cord samples was 81%, whereas in the seven adult samples the mean was 87%. Speculation: Experimental evidence has suggested that the neutrophil of the newborn may be immature compared with that of the adult. In this study we determined that the average percentage of neutrophils possessing complement and Fc receptors in cord blood of normal infants and in adult peripheral blood was identical. Infants suffering from neonatal disorders, including sepsis should be studied for the presence or absence of these receptors.

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