Mechanism of Acute Hypotension Following Total Body Irradiation.

Publisher Website
Google Scholar
Abstract
Adult white rats given from 1500 to 2500 r total body irradiation developed acute hypotension within 6 hrs. which lasted for 30 hrs. The avg. mean pressure by aortic puncture was 70 mm. Hg. There was no accompanying change in blood volume (by P32 technic) or in the hematocrit. Complete adrenalectomy did not influence the results. Transection of the spinal cord at C6 resulted in an identical picture, which was not influenced by subsequent total body radiation. It was concluded that central nervous system depression is the cause of the hypotension following large doses of total body radiation.

This publication has 2 references indexed in Scilit: