Variant surface glycoproteins of Trypanosoma brucei are synthesised with cleavable hydrophobic sequences at the carboxy and amino termini
Open Access
- 25 September 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 9 (18) , 4735-4743
- https://doi.org/10.1093/nar/9.18.4735
Abstract
CDNAs coding for the amino and carboxy termini of two trypanosome variant surface glycoproteins (VSGs) have been sequenced. The results indicate that VSGs are synthesised with hydrophobic amino-terminal leader and carboxy-terminal tail sequences which are absent from purified mature VSGs.Keywords
This publication has 18 references indexed in Scilit:
- A variant surface glycoprotein of Trypanosoma brucei synthesized with a C-terminal hydrophobic ‘tail’ absent from purified glycoproteinNature, 1980
- Evaluation of the “scanning model” for initiation of protein synthesis in eucaryotesCell, 1980
- Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chainCell, 1980
- Novel expression-linked copies of the genes for variant surface antigens in trypanosomesNature, 1980
- The mechanism of protein secretion across membranesNature, 1980
- Antigenic variation in trypanosomesProceedings of the Royal Society of London. B. Biological Sciences, 1978
- Antigenic variation in trypanosomesNature, 1978
- N-terminal amino acid sequences of variant-specific surface antigens from Trypanosoma bruceiNature, 1976
- 3′ Non-coding region sequences in eukaryotic messenger RNANature, 1976
- Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat ofTrypanosoma bruceiParasitology, 1975