Efficient Asymmetric Epoxidation of α,β-Unsaturated Ketones Using a Soluble Triblock Polyethylene Glycol−Polyamino Acid Catalyst

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Abstract
[reaction: see text]. Polyethylene glycol (PEG)-bound poly-L-leucine acts as a THF-soluble catalyst for the Juliá-Colonna asymmetric epoxidation of enones. Excellent enantioselectivities may be obtained even with short chain length polyleucine. FT-IR investigations have determined that the catalytically active polyleucine components of these copolymers have an alpha-helical structure.