CHANGES IN SERUM PHOSPHATE AND CALCIUM AND THEIR RELATION TO MANIFESTATIONS OF TRAUMATIC SHOCK

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Abstract
A rise in serum phosphate accompanies shock produced by tourniquets on the hind legs of dogs. No large changes occur in the total serum Ca or in the "K" values of the electrocardiogram. Infusion of phosphate in the anesthetized animal is followed by increase in serum phosphate, loss of total serum Ca, fall in blood pressure, hemoconc, tetanic muscular contractions, prolongation of the relative electrical ventricular systole (K value) and death. Infusion of citrate in the anesthetized animal does not influence blood pressure until the terminal moments of life, only moderate hemo-concentration occurs but there is marked loss of plasma protein. The total serum Ca tends to rise even though tetanic muscular contractions and alteration of the electrical ventricular systole are outspoken. The atropinized animal survives the infusion of more than twice the amt. of citrate which is fatal without the use of this drug. The only other difference manifested is a decrease in the loss of plasma protein. These findings provide a basis for consideration of the mechanisms involved in permeability of the capillary wall.

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